MediaCore is a free open source video CMS and podcast platform that you can install on your own server. With a slick, web 2.0-ish look and feel, the UI is well polished and the application supports all the features you would expect including browsing, search, video and audio upload, comments and moderation, tags and more. Not only can you upload videos, but MediaCore also supports YouTube videos as well. For audio and video syndication, you can have unlimited episodes with both Feedburner RSS and iTunes support.
My only real complaint is that it is programmed in Python (as opposed to PHP which powers WordPress and many other open source software) which may turn away less technical users and those on shared hosting accounts without Python support. With that said, this is by far one of the best designed open source applications I have seen and a great tool to syndicate video on the web.
If you produce audio or video show for the web or need a easy way to showcase videos for your company website or intranet, you should check out MediaCore today.
Learn more, view a demo and download MediaCore at: http://getmediacore.com/